Principles of Cell Biology

This subject develops a student’s knowledge of cell biology, introduced in second year subjects. The subject describes the molecular mechanisms underpinning eukaryotic cell and tissue organisation, morphology and behaviour and their importance in biomedicine. We will explore the relationships between cellular organisation and the biological functions of normal and stressed cells, as well as experimental strategies for investigating the molecular basis of these relationships. The subject matter includes the compartmentalisation of eukaryotic cells; intracellular trafficking of biomolecules; the structure, function and biogenesis of subcellular organelles; protein folding and maturation; vesicle-mediated transport; structure and function of the extracellular matrix and cell adhesion molecules and their role in diseased states such as malignancies; cellular stress responses and linked signal transduction events; cytoskeletal structures and the signal transduction processes regulating the assembly and disassembly of actin-cytoskeleton; molecular processes determining cell movement and shape changes; imaging of processes within live cells. Students will also gain an appreciation of the major concepts involved in the development of a range of organisms. This multi-disciplinary subject is co-taught by staff in the School of Biomedical Sciences and School of BioSciences. A feature of this subject is the application of this knowledge in pure and applied research and thus will provide a platform for students in many Life Science majors.

• 1Explain current concepts concerning the molecular basis of genome structure and regulation of gene transcription and translation, including regulation by non-coding RNA
• 2Explain the common principles that govern protein trafficking, cell adhesion, cell migration, and cell signalling pathways in eukaryotic cells, and how cell and tissue interactions shape a developing organism
• 3Describe genetic, molecular and cellular techniques used to investigate developmental and cell biological processes in various cells and organisms
• 4Analyse and evaluate scientific data and literature, including imaging data using computer-based software, integrating relevant concepts and skills
• 5Synthesise scientific literature to construct arguments and communicate findings to expert and non-expert audiences
• 6Apply scientific research and quantitative skills to develop broad experimental approaches to investigate molecular and cellular functions involved in developmental processes
• 7Discuss the design, choice, use and ethical considerations of model organisms and cell lines in molecular cell biology
• 8Work effectively in diverse groups to investigate and communicate concepts in cell and developmental biology